BALTIMORE (AP) -- Brandon Dixon hit a tiebreaking two-run homer in the ninth inning to lead Detroit past Baltimore.
The Tigers took two of the three games and won their first road series since April 1-3 against the Yankees.
Orioles reliever Mychal Givens allowed a solo homer to John Hicks that tied the game 2-2 in the eighth.
Nicholas Castellanos walked to lead off the ninth and Dixon followed with a two-run shot off Branden Kline (1-2).
Nick Ramirez (1-0) didn't allow a hit over three innings of relief. Shane Greene gave up a two-out double to Stevie Wilkerson in the ninth but still picked up his 18th save.
Keon Broxton got his second homer for Baltimore.
Rookie left-hander John Means allowed one run and three hits with a season-high seven strikeouts and no walks over six innings for the Orioles, who have lost 13 of 16.