Crews will begin demolishing the former Detroit Animal Care and Control Center Monday morning.
The building sits at the corner of Jefferson and East Grand Boulevard.
After demolition is complete, the 3-acre site will become part of Riverside Park, which is undergoing major expansion and renovations.
The area will become a marquee waterfront amenity for the residents of Southwest Detroit.
A portion of the Animal Control site will become a new dog park.
Construction is expected to begin later this year.