MINNEAPOLIS (AP) -- Jordan Zimmermann hasn't required much run support this year. Justin Upton gave him all he needed in the first inning Saturday.
Zimmermann won his fifth straight start to begin his first season with Detroit, and Upton hit a three-run homer for the Tigers in their 4-1 victory over the Minnesota Twins.
"Give him a three-run lead, we're pretty confident he can work with that," said Upton, whose second homer of the year reached the second deck in left-center. "If we can fight and get on the board early, and let our guys work, we'll be all right."
Zimmermann (5-0) gave up one run and six hits with no walks and seven strikeouts over seven innings. His ERA actually rose to 0.55 as he became the first Tigers pitcher to win five games in April since Frank Tanana in 1988, according to STATS.
Upton and Zimmermann both signed as free agents with Detroit for more than $100 million this past offseason. Zimmermann knew he would be joining a team with a high-octane offense, though he hasn't relied on the Tigers' bats much yet.
"This is probably the best lineup I've ever seen," Zimmermann said. "They're going to score runs. It's just a matter of when and what inning. For me, they've been scoring early and allowing me to settle in and just throw strikes."
Victor Martinez doubled twice for the Tigers, who have won five of six. Francisco Rodriguez pitched a scoreless ninth for his sixth save in seven opportunities.
Eduardo Escobar had three singles for the Twins, who lost their third straight and fell to 7-17 overall.
Tyler Duffey (0-1) gave up just one earned run in 6 1/3 innings, striking out seven and walking none. But one mistake in the first marred an otherwise solid performance.
With two on and two outs, Duffey tried to get ahead in the count with a first-pitch fastball. But the pitch caught too much of the plate and Upton drove it an estimated 417 feet for his second homer with Detroit.
"It's easy to look back and say I should have gotten out of that. I know I was more than capable of doing it," Duffey said. "That mistake is a lot larger when you've got a guy like Zimmermann throwing against you."
Zimmermann cruised through the first three innings, but Byung Ho Park homered in the fourth to break up the shutout. Park lined a 1-2 pitch into the bullpen in left-center, his team-leading sixth homer of the year.
It was the first home run allowed by Zimmermann in 29 2/3 innings this season.
After that, each time the Twins threatened, Zimmermann had an answer. John Ryan Murphy reached second on an error by right fielder J.D. Martinez with one out in the fifth before Zimmermann struck out Danny Santana and Brian Dozier to preserve the two-run cushion.
Minnesota got its leadoff man on in the seventh, but Zimmermann promptly induced a double-play grounder from Eddie Rosario.
CATCHER KNOWS BEST
Zimmermann might have kept the Twins off the board entirely if he'd just listened to catcher Jarrod Saltalamacchia, who didn't want to throw Park the slider he hit into the bullpen.
"That was really my only mistake all game. I tried going front door with it, and obviously that wasn't the right pitch. I'm sure Salty will say the same thing. He didn't really want to throw it and I did, so that was my fault," Zimmermann said. "It didn't work out, but solo home runs aren't going to kill you, so it's all good."
Tigers: C James McCann (sprained ankle) caught nine innings for Triple-A Toledo on Friday, but manager Brad Ausmus said McCann will continue his rehab assignment through the weekend. McCann was expected to catch nine more innings Saturday and five innings on Sunday before rejoining the Tigers for their three-game series in Cleveland that begins Tuesday.
Twins: 3B Trevor Plouffe (strained intercostal muscle) was scheduled to begin a rehab assignment with Class A Fort Myers on Saturday. Plouffe has been on the DL since April 19. Barring any setbacks, he is expected to join the Twins in Houston on Tuesday.
Tigers: RHP Mike Pelfrey (0-4, 4.64 ERA) faces his former team in Sunday's series finale. Pelfrey spent the past three seasons in Minnesota. He pitched a season-high 6 2/3 innings in his most recent start, a 5-1 loss to the Athletics on Tuesday.
Twins: RHP Ricky Nolasco (1-0, 3.25) has been the team's most effective starter this season. He's averaged just shy of seven innings in his four starts and is second in the AL in strikeout-to-walk ratio with 24 strikeouts against three walks.